Neurobiology of Disease Cleavage of the Vesicular GABA Transporter under Excitotoxic Conditions Is Followed by Accumulation of the Truncated Transporter in Nonsynaptic Sites
نویسندگان
چکیده
João R. Gomes,1,2 Andrea C. Lobo,1,2 Carlos V. Melo,1 Ana R. Inácio,4 Jiro Takano,5 Nobuhisa Iwata,5 Takaomi C. Saido,5 Luís P. de Almeida,1,3 Tadeusz Wieloch,4 and Carlos B. Duarte1,2 1Center for Neuroscience and Cell Biology, 2Department of Life Sciences, and 3Faculty of Pharmacy, University of Coimbra, 3004-517 Coimbra, Portugal, 4Wallenberg Neuroscience Center, Lund University, 221 84 Lund, Sweden, and 5RIKEN Brain Science Institute, Hirosawa, Wako-shi, Saitama, 351-0198, Japan
منابع مشابه
Cleavage of the vesicular GABA transporter under excitotoxic conditions is followed by accumulation of the truncated transporter in nonsynaptic sites.
GABA is the major inhibitory neurotransmitter in the CNS and changes in GABAergic neurotransmission affect the overall activity of neuronal networks. The uptake of GABA into synaptic vesicles is mediated by the vesicular GABA transporter (VGAT), and changes in the expression of the transporter directly regulate neurotransmitter release. In this work we investigated the changes in VGAT protein l...
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